Figure 6.
Resolvin E1 (RvE1), but not resolvin D1 (RvD1), counterregulates leukotriene B4 (LTB4)–induced glycoprotein secretion in goblet cells. Cultured rat goblet cells were stimulated with LTB4 (10−10 mol/L), RvE1 (10−8 mol/L), or RvD1 (10−8 mol/L) alone or incubated with RvE1 or RvD1 for 30 minutes prior to addition of LTB4 for 2 hours. Glycoprotein secretion was measured. The average fold increase above basal, which was set to 1, is shown. One-way analysis of variance nonparametric with Dunn multiple comparisons was used. Data are expressed as individual data points from each animal and means ± SEM. n = 5 rats. ∗P < 0.05 versus basal; †P < 0.05 versus LTB4 alone.