Table 3.
Number of clinical trials available by drug and age or age-related condition. On ClinicalTrials.gov, “condition/disease” is defined as “the disease, disorder, syndrome, illness, or injury that is being studied”. We found ∼12,100 clinical trials that target age or age-related diseases with 510 clinical trials aimed toward “Aging as a condition or disease”. Of note, we have added anti-aging interventions such as CR, exercise, fasting, and ketogenic diet, although they are not the focus of the review. To date, exercise is the “anti-aging” intervention with the most on-going clinical trials.
| DRUGS | AGING* | AD** | AMD | CANCER | CDV | FRAILTY | MET.S** | OSTEOA | OSTEOP | PD | SARCOPENIA | T2D*** |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACARBOSE | 2 | 0 | 0 | 4 | 19 | 0 | 1 | 0 | 0 | 0 | 0 | 67 |
| ASPIRIN | 1 | 0 | 3 | 161 | 1008 | 0 | 3 | 2 | 0 | 0 | 0 | 53 |
| CURCUMIN | 9 | 5 | 0 | 65 | 8 | 0 | 7 | 4 | 0 | 0 | 0 | 8 |
| GDF8 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 |
| GREEN TEA | 5 | 0 | 0 | 97 | 31 | 0 | 2 | 1 | 1 | 1 | 0 | 17 |
| METFORMIN | 11 | 3 | 1 | 335 | 105 | 4 | 62 | 0 | 0 | 0 | 1 | 1337 |
| METHYLENE BLUE | 1 | 7 | 0 | 43 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| NAD_NAD precursors | 12 | 2 | 0 | 13 | 57 | 1 | 9 | 0 | 0 | 0 | 2 | 9 |
| POLYAMINES | 1 | 2 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| QUERCETIN | 2 | 1 | 0 | 13 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| RAPAMYCIN | 11 | 0 | 12 | 1106 | 473 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| RESVERATROL | 10 | 5 | 2 | 15 | 10 | 0 | 13 | 1 | 2 | 6 | 1 | 15 |
| SRT2104 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 7 |
| SRT3025 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| SIMVASTATIN | 1 | 8 | 0 | 58 | 172 | 0 | 14 | 0 | 1 | 1 | 0 | 42 |
| TRYPTOPHAN | 0 | 2 | 0 | 3 | 9 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| INTERVENTIONS | ||||||||||||
| CALORIC RESTRICTION | 15 | 7 | 0 | 57 | 20 | 0 | 22 | 3 | 0 | 0 | 0 | 31 |
| EXERCISE | 435 | 167 | 0 | 1214 | 1979 | 80 | 229 | 331 | 93 | 179 | 121 | 628 |
| FASTING | 20 | 21 | 2 | 281 | 240 | 0 | 50 | 15 | 12 | 22 | 4 | 339 |
| KETOGENIC DIET | 0 | 9 | 0 | 26 | 4 | 0 | 2 | 0 | 0 | 2 | 0 | 7 |
| TOTAL | 538 | 239 | 20 | 3496 | 4141 | 85 | 414 | 357 | 109 | 212 | 134 | 2564 |
Includes age, aging and longevity.
Includes Alzheimer’s disease, dementia and mild cognitive impairment; AD (Alzheimer’s disease); CDV (cardiovascular disease); Met.S (metabolic syndrome); Osteoa (osteoarthritis); Osteop (osteoporosis); PD (Parkinson’s disease); T2D (type 2 diabetes).