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The pancreatic tumor microenvironment exhibits immunosuppressive properties.
Pancreatic cancer cells, several stromal cell types, some altered microorganisms and some non-cellular stromal components can suppress anti-tumor cytotoxic T-cell responses. Tumor-associated macrophage (TAM); regulatory T-cell (Treg); myeloid-derived suppressor cell (MDSC); cancer-associated fibroblast (CAF); T lymphocyte expresses γ and δ TCR chain (γδ T-cell); extracellular matrix (ECM).
