Table 3.

Summary of key drug resistance-related miRNAs which are identified as biomarkers (diagnostic and prognostic value) in CRC.

miRNA	Alteration	Potential values	Ref
miR-17-5p	Up	High level of miR-17-5p predicts poorer survival and poor response to chemotherapy	Fang et al.23
miR-7	Down	Low level of miR-7 predicts poorer survival	Suto et al.26
miR-204-5p	Down	Low level of miR-204-5p predicts poorer survival	Yin et al.30
miR-182	Up	diagnostic marker for CRC	Liu et al.33
miR-199a/b	Up	High level of miR-199a/b predicts poorer survival	Chen et al.41
miR-19b-3p	Up	High level of miR-19b-3p predicts poorer survival	Jiang et al.43
miR-218	Down	Low level of miR-218 predicts poorer survival and poor response to chemotherapy	Li et al.52
miR-1290	Up	High level of miR-1290 predicts poorer survival	Ye et al.119
miR-506	Down	Low level of miR-506 predicts poorer survival	Zhou et al.67
miR-10b	Up	High level of miR-10b predicts poorer survival	Nishida et al.78
miR-143	Down	diagnostic marker for CRC; Low level of miR-143 predicts poor response to chemotherapy	Qian et al.83
miR-338-3p	Up	High level of miR-338-3p predicts poorer survival	Han et al.94
miR-196b-5p	Up	diagnostic marker for CRC	Ren et al.97
miR-128	Down	Low level of miR-128 predicts poorer survival	Lu et al.113
miR-1914* /1915	Down	diagnostic marker for CRC	Hu et al.120
miR-21	Up	High level of miR-21 predicts poorer survival and poor response to chemotherapy	Kulda et al.121

CRC, colorectal cancer; miRNAs, microRNAs.