Table 2.

Step 2 (E): Echocardiographic and Natriuretic Peptide Heart Failure with Preserved Ejection Fraction Workup and Scoring System (Diagnostic Workup)

Functional	Morphological	Biomarker (Sinus Rhythm)	Biomarker (Atrial Fibrillation)
septal e´ < 7 cm/s or lateral e´ < 10 cm/s or average E/e´ ≥ 15 or TR velocity > 2.8 m/s (PASP > 35 mm Hg)	LAVI > 34 mL/m2 or LVMI ≥ 149/122g/m2 (m/w) and RWT>0,42	NT-pro BNP > 220 pg/mL or BNP > 80 pg/mL	NT-pro BNP > 660 pg/mL or BNP > 240 pg/mL
Average E/e´ 9–14 or GLS < 16%	LAVI 29–34 mL/m2 or LVMI > 115/95g/m2 (m/w) or RWT>0,42 or LV wall thickness ≥ 12 mm	NT-pro BNP 125–220 pg/mL or BNP 35–80 pg/mL	NT-pro BNP 365–660 pg/mL or BNP 105–240 pg/mL

Note: Data from Pieske et al.5