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. Author manuscript; available in PMC: 2020 Aug 27.
Published in final edited form as: Biochemistry. 2019 Oct 28;58(44):4447–4455. doi: 10.1021/acs.biochem.9b00805

Figure 4.

Figure 4.

Effects of GSK126 on DNA cleavage mediated by wild-type (WT) and fluoroquinolone-resistant gyrase. The effects of GSK126 on single-stranded (SS, filled circles) and double-stranded (DS, empty circles) DNA cleavage mediated by WT (solid line) and fluoroquinolone-resistant (dashed line) B. anthracis WT and GyrAS85L (left, red), E. coli WT and GyrAS83L (middle, green), and M. tuberculosis WT and GyrAA90V (right, orange) gyrase are shown. Some of the data shown for M. tuberculosis WT and GyrAA90V gyrase are from Gibson et. al.30 Error bars represent the SD of at least three independent experiments. Representative agarose gels are shown in Figure S2.