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. Author manuscript; available in PMC: 2020 Aug 27.
Published in final edited form as: Biochemistry. 2019 Oct 28;58(44):4447–4455. doi: 10.1021/acs.biochem.9b00805

Figure 8.

Figure 8.

GSK126 inhibits DNA decatenation catalyzed by wild-type (WT) and fluoroquinolone-resistant topoisomerase IV. The effects of GSK126 on DNA decatenation by WT (filled circles) and fluoroquinolone-resistant (empty circles) B. anthracis WT and GrlAS81F (top left, purple) and E. coli WT and ParCS80L (top right, blue) topoisomerase IV are shown. Error bars represent the SD of at least three independent experiments. The bottom panel shows a table of IC50 values. Representative agarose gels are shown in Figure S6.