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. Author manuscript; available in PMC: 2020 Aug 27.
Published in final edited form as: Biochemistry. 2019 Oct 28;58(44):4447–4455. doi: 10.1021/acs.biochem.9b00805

Figure 9.

Figure 9.

Effects of GSK126 on DNA cleavage mediated by wild-type (WT) and fluoroquinolone-resistant topoisomerase IV. The effects of GSK126 on single-stranded (SS, filled circles) and double-stranded (DS, empty circles) DNA cleavage mediated by WT (solid line) and fluoroquinolone-resistant (dashed line) B. anthracis WT and GrlAS81F (left, purple) and E. coli WT and ParCS80L (right, blue) topoisomerase IV are shown. Error bars represent the SD of at least three independent experiments. Representative agarose gels are shown in Figure S7.