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. Author manuscript; available in PMC: 2020 Aug 27.
Published in final edited form as: J Am Chem Soc. 2015 Apr 16;137(16):5363–5371. doi: 10.1021/ja5117809

Figure 6.

Figure 6.

(a) Cartoon image illustrating beta-beta dimer topology. (b) Designed structure; validated by 2D NMR NOEs & CSDs. Selected, structurally diagnostic NOEs are marked as orange lines (intrachain) and purple lines (interchain). (c) A slice of the NOESY spectra showing the structurally-diagnostic contacts highlighted in the upper right panel, here as raw NOEs. (Complete NMR data appear in the Supporting Information). (d) CD-derived melting plot; intensity vs. temperature. (Trp/Trp exciton couplet maxima at 228nm.) The reduced form still adopts a fully-folded hairpin. NMR data (see Supporting Information) suggest that the reduced species remains monomeric, and that the intrachain Trp/Trp interaction (present in both oxidized dimer and reduced monomer) produces a stronger exciton couplet than the interchain Trp/Trp (oxidized dimer only) pair.