Table 1.
(A) Top panel shows list of individual cases, their demographics, pathological score at autopsy and randomization of samples for Tandem Mass Tag isobaric 10-plex multiplexing. (B) Bottom panel shows mean estimates of relevant demographics, post-mortem interval (PMI) time, pathological score at autopsy for patients across the three different populations investigated
| A | ||||||||
| Cases | Disease | CDR score | Sex (M/F) | Mean plaque score | Braak-staging (I-VI) | TMT isobaric label | Plex group | |
| 1 | Healthy Controls | 0 | F | 0 | 0 | -128C | Plex A | |
| 2 | Healthy Controls | 0 | F | 0 | I | -128N | Plex A | |
| 3 | Healthy Controls | 0 | M | 0 | I | -129C | Plex A | |
| 4 | Healthy Controls | 0.5 | M | 0 | II | -128C | Plex B | |
| 5 | Healthy Controls | 0 | M | 0.26 | II | -128N | Plex B | |
| 6 | Healthy Controls | 0 | M | 0 | 0 | -131 [ref] | Plex A, B, C | |
| 7 | Healthy Controls | 0.5 | F | 0 | II | -129C | Plex B | |
| 8 | Healthy Controls | 0.5 | M | 0 | I | -126 | Plex C | |
| 9 | Healthy Controls | 0 | F | 0 | 0 | -127C | Plex C | |
| 10 | Nonagenerians | 0 | F | 5.356 | V | -127N | Plex B | |
| 11 | Nonagenerians | 0 | F | 1.944 | IV | -126 | Plex A | |
| 12 | Nonagenerians | 0.5 | F | 3.754 | IV | -127C | Plex A | |
| 13 | Nonagenerians | 0 | M | 1.95 | IV | -127N | Plex A | |
| 14 | Nonagenerians | 0.5 | F | 7.49 | V | -126 | Plex B | |
| 15 | Nonagenerians | 0.5 | F | 7.49 | VI | -127C | Plex A | |
| 16 | Alzheimer's Disease | 4 | M | 29.76 | VI | -129N | Plex A | |
| 17 | Alzheimer's Disease | 3 | M | 18.88 | VI | -130C | Plex A | |
| 18 | Alzheimer's Disease | 2 | F | 19.12 | VI | -130N | Plex A | |
| 19 | Alzheimer's Disease | 2 | F | 20.24 | VI | -129C | Plex C | |
| 20 | Alzheimer's Disease | 1 | M | 6.72 | VI | -128C | Plex C | |
| 21 | Alzheimer's Disease | 2 | M | 12.58 | VI | -130C | Plex C | |
| 22 | Alzheimer's Disease | 3 | F | 9.17 | VI | -127N | Plex C | |
| 23 | Alzheimer's Disease | 1 | F | 24.15 | VI | -129N | Plex B | |
| 24 | Alzheimer's Disease | 3 | F | 20.48 | VI | -130C | Plex B | |
| 25 | Alzheimer's Disease | 2 | M | 22.47 | VI | -130N | Plex B | |
| 26 | Alzheimer's Disease | 3 | F | 31.96 | VI | -128N | Plex C | |
| B | ||||||||
| Disease group | Mean PMI mins (±SEM) | Mean CDR score (±SEM) | Mean age Yrs (±SEM) | Male (%) | Female (%) | Mean plaque score (±SEM) | Braak-staging (±SEM) | Sample size (N) |
| Healthy Control | 601.6±94.6 | 0.17±0.08 | 77.2±0.6 | 55.6% (5/9) | 44.4% (4/9) | 0.03±0.03 | 1±0.3 | 9 |
| Nonagenerians | 448±110.7 | 0.25±0.11 | 93.2±1.1 | 16.7% (1/6) | 83.3% (5/6) | 4.66±1.03 | 4.67±0.3 | 6 |
| Alzheimer's Disease | 441.8±76.2 | 2.36±0.28 | 77.0±0.5 | 45.5% (5/11) | 54.5% (5/11) | 19.59±2.36 | 6±0.0 | 11 |