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Identification of potential signaling pathways of omipalisib with RNA-seq assays. (A, B) DEGs indicated that the mTOR signaling pathway is the major pathway affected by omipalisib treatment according to KEGG pathway enrichment analysis (A) and GSEA (B). (C) qRT-PCR assays showed obvious alterations in DDIT4 and CCND1 gene expression, and the tendency was consistent with the RNA-seq results. (*** P<0.001).
