Table 1.

EC₅₀ of 5 compounds for growth inhibition in Esophageal squamous cell carcinoma (ESCC) cell lines.

Compound	Target	EC50 for 4 OSCC cells (nM, SD)
		KYSE70	KYSE150	KYSE180	KYSE520
Carfilzomib	Proteasome	22.78±7.99	8.20±1.26	15.74±1.32	14.61±4.60
Delanzomib	Proteasome	32.85±3.44	12.90±1.43	33.53±5.58	44.22±14.24
Ixazomib	20S proteasome	253.97±132.90	355.09±195.70	237.03±92.29	163.21±67.37
Digoxin	Na+, K+-ATPase	121.98±24.37	294.85±43.17	304.27±36.29	185.17±36.09
Omipalisib	PI3K/mTOR	138.87±10.18	163.80±21.34	160.17±30.14	122.59±26.03

EC₅₀ – concentration for 50% of maximal effect; SD – standard deviation.