Table 1.
Timing of Measurements
| Study Period | ||||||
|---|---|---|---|---|---|---|
| Screening | Allocation | Experimental Sessions (1, 2, 3) | ||||
| Prestudy Drug | Pre-CIC | Post-CIC Water | Post-CIC Alcohol | |||
| Enrollment | X | |||||
| Eligibility screen | X | |||||
| Informed consent | X | |||||
| Drug order allocation | X | |||||
| Assessments | ||||||
| Sociodemographic | X | |||||
| AUDIT | X | |||||
| SCID-5 | X | |||||
| CAPS-5 | X | |||||
| CIWA-Ar | X | X | ||||
| Urine toxicology | X | X | ||||
| Breath alcohol concentration | X | X | ||||
| Cue-induced craving task | ||||||
| Self-reported craving | X | X | X | X | ||
| ECG recording | X | X | X | X | ||
AUDIT, Alcohol Use Disorders Identification Test; CAPS-5, Clinician-Administered PTSD Scale for DSM-5; CIC, cue-induced craving; CIWA-Ar, Clinical Institute Withdrawal Assessment of Alcohol Scale, Revised; ECG, electrocardiogram; SCID-5, Structured Clinical Interview for DSM-5.