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a) Comparison of normalized change in ctDNA mutations (ΔVAF) with relative change in mutations cancer cell fractions (ΔCCF). The analysis includes 256 mutations. b) Comparison of estimated CCF based on combined tumor and ctDNA approach (Methods) with CCF estimated based on ctDNA-only approach54,55. The analysis includes 379 mutations. Pearson’s correlation coefficients (R) and two-sided p values are provided.
