Table 2.

Cumulated number of cancers in different high and low risk subgroups at 6-, 12- and 24-months follow up visits after the S2 screening date

		Number of individuals	Cumulative number of cancers diagnosed at follow up visit
			6 months	12 months	24 months	36 months
NLST training sample
Total screened		25097	274	358	464	574
High-risk subgroup	Lung-RADS=4B	561	170	194	212	221
	Lung-RADS= 4A/4B/4X	1333	227	274	308	327
	ML>0.3	392	260	313	344	353
Low-risk subgroup	Lung-RADS=1 or 2	23458	43	75	145	234
	ML ≤ 0.1	24234	6	15	51	95
PanCan validation sample
Total screened		2294	43	54	72	92
High-risk subgroup	Lung-RADS=4B	97	35	38	44	49
	Lung-RADS=4A/4B/4X	235	41	48	58	65
	VDT < 400 days	192	29	31	36	44
	ML>0.3	221	41	51	61	65
Low-risk subgroup	Lung-RADS=1 or 2	1698	1	3	9	20
	ML ≤ 0.1	1266	0	0	2	10
	VDT >600 days	2075	13	19	31	43