Fig. 3.

Elevated lytic activity on post-op day-1 high dose tPA TEG is associated in increased pre-operative sensitivity to tPA-mediated fibrinolysis. On post-op day-1, patients with > or = 23% lysis 30 min after maximum amplitude on a TEG with 150 ng/ml of exogenous tPA (“POD-1 tPA 150”, orange bars) were considered to have a “positive high dose tPA TEG LY30”. These patients demonstrated significantly more lysis in preoperative tPA challenge TEGs, with both high (150 ng/ml, pre-op tPA 150, purple bars) and low doses (75 ng/ml, “pre-op tPA 75”, blue bars) of exogenous tPA, compared to patients who had negative (<23% lysis) high dose tPA TEG LY30s on post-op day 1. No difference was observed between cohorts on pre-op native TEGs (“pre-op tPA 0”, teal bars), post-op native TEGs (“POD-1 tPA 0”, brown bars), and post-op low dose tPA TEGs (“POD-1 tPA 75”, gold bars). ∗, ∗∗, and ∗∗∗ denote statistical significance (p < 0.05). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)