Table 4.

Factors associated with severity of COVID-19

	Univariate logistic regression			Multivariate logistic regression
	OR	95% CI	P value	OR	95% CI	P value
Age  >65 years	1.81	1.18–2.78	0.006	1.81	1.08–3.03	0.024
Males	1.36	0.89–2.08	0.152	0.69	0.41–1.16	0.162
Shortness of breath	1.92	1.25–2.94	0.003	1.48	0.91–2.42	0.115
Laboratory findings
White blood cell count > 10 × 10^9/L	7.53	3.87–14.65	< 0.001	–	–	–
Neutrophil count > 7 × 10^9/L	7.60	4.21–13.74	< 0.001	2.31	1.12–4.77	0.024
Lymphocyte count < 0.6 × 10^9/L	3.55	2.11–5.99	< 0.001	1.23	0.66–2.29	0.522
Hemoglobin > 110 g/L	1.29	0.65–2.54	0.468	–	–	–
Platelet count < 100 × 10^9/L	2.38	1.45–3.93	0.001	2.09	1.15–3.79	0.015
Albumin < 30 g/L	4.11	2.36–7.16	< 0.001	1.02	0.49–2.12	0.959
Blood bicarbonate ions < 20 mmol/L	2.89	1.69–4.92	< 0.001	1.27	0.67–2.38	0.466
Blood urea nitrogen > 6 mmol/L	5.81	3.41–9.89	< 0.001	1.58	0.79–3.14	0.194
Blood creatinine > 100 μmol/L	2.84	1.66–4.85	< 0.001	1.14	0.56–2.31	0.717
Lactate dehydrogenase > 400 U/L	16.57	8.80–31.20	< 0.001	5.45	2.42–12.26	< 0.001
High-sensitivity C-reactive protein > 90 mg/L	4.83	2.84–8.21	< 0.001	1.21	0.58–2.50	0.615
Procalcitonin > 0.2 ng/mL	6.29	3.64–10.85	< 0.001	1.45	0.67–3.17	0.347
Ferritin > 1000 μg/L	4.06	2.42–6.82	< 0.001	1.06	0.52–2.13	0.876
Soluble interlukin-2 receptor > 1200 U/mL	5.20	3.06–8.86	< 0.001	1.60	0.78–3.30	0.198
Interlukin-6 > 50 pg/mL	4.88	2.86–8.33	< 0.001	2.02	1.11–4.03	0.045
Interlukin-8 > 25 pg/mL	2.65	1.61–4.36	< 0.001	1.10	0.61–2.00	0.749
Interlukin-10 > 10 pg/mL	2.77	1.70–4.52	< 0.001	1.30	0.72–2.35	0.383
Tumor necrosis factor alpha > 10 pg/mL	1.96	1.20–3.20	0.007	0.71	0.37–1.36	0.308
hsCRP/lymphocyte > 120 × 10^9 mg	7.14	4.10–12.44	< 0.001	–	–	–