Fig. 8.

Histological analyses of different treatments for 2 or 6 weeks. a H&E (upper) and safranin-O/fast green staining (lower) of cartilage sections after the treatments with PBS, PSO, MR-PPL@PSO and MRC-PPL@PSO. Scale bar = 1 mm. b OARSI scores of articular cartilage after the treatments. Each data points represents mean ± S.D. (n = 5). *, # indicate p < 0.05; **, ## indicate p < 0.01; ***, ### indicate p < 0.001. c Immunohistochemical staining of MMP-13 on cartilage sections after the treatments. Scale bar = 300 μm