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. 2019 Dec 16;11(1):18–29. doi: 10.1039/c9md00396g

Fig. 10. Scaffold-hopping can be carried out on multiple sites in a molecule to impart desirable metabolic properties. By replacing three separate heterocycles, Raheem et al.62 used scaffold-hopping to enhance metabolic stability and reduce off-target effects.

Fig. 10