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. 2019 Dec 16;11(1):18–29. doi: 10.1039/c9md00396g

Fig. 4. Computational methods can be used to identify new scaffolds. Wavhale et al.51 used the rapid overlay of chemical structures (ROCS) program to scaffold-hop from pyrrole to benzimidazole, which conserved important aspects of the three-dimensional structure.

Fig. 4