Fig. 3.

Surface plasticity of the Phl p 7 variant with the four mutated calcium ion stabilizing residues. Compared to the wildtype, the surface plasticity of the Phl p 7 variant reveals simulated free in solution, without ions and bound to the antibody substantially higher surface plasticity. This is in line with the lower thermostability and the decreased capacity to bind to the IgE Fab. The orientations of the Phl p 7 molecules are the same in all pictures and are shown in complex with the IgE Fab on the right.