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. Author manuscript; available in PMC: 2020 Aug 27.
Published in final edited form as: Nat Genet. 2019 Nov 29;51(12):1679–1690. doi: 10.1038/s41588-019-0539-z

Figure 4 |. Identification of mutant NRXN1α isoforms.

Figure 4 |

a, Schematic of NRXN1α isoform structure, with each row representing a unique NRXN1α isoform and each column representing a NRXN1 exon. Colored exons (red, 3’-NRXN1+/− specific; gray, control specific; orange, shared) are spliced into the transcript while blank exons are spliced out. b, log2(foldchange) of each NRXN1α isoform in 3’-NRXN1+/− hiPSC-neurons (2 donors) compared to control hiPSC-neurons (2 donors). c, Abundance of each NRXN1α isoform across 3’-NRXN1+/− and control hiPSC-neurons. d, Validation of each isoform in postmortem samples (black, expressed in postmortem PFC). e, Pearson’s correlation of 47 NRXN1α isoforms between hiPSC-neurons (forebrain) and ASCL1/DLX2-GABAergic neurons from 3’-NRXN1+/− (1 donor) and controls (1 donor) with two-sized t-test. f, Pearson’s correlation of 57 NRXN1α isoforms between hiPSC-neurons (forebrain) and NGN2-glutamatergic neurons from 3’-NRXN1+/− (1 donor) and controls (1 donor) with two-sized t-test.