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. Author manuscript; available in PMC: 2020 Aug 27.
Published in final edited form as: Minerva Med. 2018 Oct 11;110(3):238–250. doi: 10.23736/S0026-4806.18.05875-5

Figure 2. Link between altered PON1 activity and AD development.

Figure 2.

This HDL-associated protein appear to play a role in the metabolism of cholesterol, by promoting the inverse cholesterol transport, and in the protection from oxidative challenges and pro-inflammatory challenges.1,23 Moreover, PON1 has been shown to protect our body from the adverse effects of OP pesticides that are considered a risk factors for AD.22,97 The finding that PON1 is also expressed in the brain further support the idea of an implication of PON1 in AD pathogenesis80 and this parallel with ours and other researchers work that have shown how the decreased serum levels of PON1 activity is linked to and increased risk of developing AD, and MCI, i.e. the so-called prodromal stage of the disease.19,48,67,71