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. Author manuscript; available in PMC: 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22;10(4):323–332.e8. doi: 10.1016/j.cels.2020.04.001

Figure 3: SCARLET scales to larger datasets and tolerates errors in copy-number profiles.

Figure 3:

(A) SCARLET results on simulated data with varying number of mutations, n = 100 cells and k = 4 copy-number profiles. (Left) Mutation matrix error; (Center) pairwise ancestral relationship error; (Right) runtime. (B) SCARLET results on simulated data with varying number of copy-number profiles, n = 100 cells and m = 20 mutations. (Left) Mutation matrix error; (Center) pairwise ancestral relationship error; (Right) runtime. (C) SCARLET results on simulated data with incorrect number of copy-number profiles. We introduce errors in the number of copy-number profiles by either merging two distinct copy-number profiles together (“Merged Profile”), or splitting one copy-number profile into two (“Split Profile”) and compare performance against the correct number of copy-number profiles.