Figure 3:

Pedigrees for representative volunteer families at 0.5% (a), 1% (b), 2.3% (c), 4.9% (d), and 10.6% (e) carrier-probailities. Volunteer is indicated with an arrow, and was chosen to be approximately 35 years old, female, and non-carriers of the BRCA founder mutations. Non-AJ family members are diagonally shaded, male relatives are denoted by blue squares, and cancer-affected, cancer-unaffected, and cancer-unknown female relatives are denoted by red, green, and grey circles respectively. Where available, age at death or interview, or cancer type and age at cancer diagnosis are given below each pedigree member.

A) Carrier-probability (CP) is low due to long cancer-free life for both grandmothers and mother, partial AJ heritage (3/4), and lack of early cancer in older sisters.

B) Long cancer-free life for mother and maternal grandmother and a lack of early cancer in a 45-year-old sister reduce CP, but lack of information about the paternal grandmother prevents further reduction.

C) An older breast cancer in mother balances with moderately long cancer-free life for both grandmothers producing an overall population-average CP.

D) Early breast cancer in mother brings the CP to 5%, despite long cancer-free life of the maternal grandmother.

E) Ovarian cancer in mother brings CP to 10%, despite long cancer-free life of maternal grandmother.