Table 1:
Personal and family characteristics of the Washington Ashkenazi Study (WAS) volunteers, for all volunteers with ½ or higher Ashkenazi Jewish (AJ) ancestry, women under 40, and women 40 or older. Characteristics given:
- Number and proportion of women with a personal history of cancer;
- Number and proportion of volunteers with no cancer reported in their family;
- Number and proportion of volunteers with no cancer reported among first-degree relatives (1DRs) and cancer reported among second-degree relatives (2DRs) or aunts;
- Number and proportion of volunteers with cancer reported among first-degree relatives (1DRs);
- Median and intra-quartile range (IQR) volunteer age;
- Number and proportion of volunteers with ½ or ¾ Ashkenazi-Jewish (AJ) ancestry;
- Mean and standard deviation (s.d.) number of cancer-free first- and second-degree female relatives;
- Number and proportion of female volunteers.
| Age Group and Characteristic | Mutation Carriers | Mutation Non- carriers |
||
|---|---|---|---|---|
| All Ages (n) | 102 | 4487 | ||
| Personal History of Cancer (Women) (n) | 23 | 31.1% | 218 | 6.9% |
| No Cancer in Reported Family (n) | 27 | 26.5% | 2546 | 56.7% |
| No Cancer in 1DRs, Cancer in 2DRs and/or Aunts (n) | 37 | 36.3% | 1177 | 26.2% |
| Cancer in 1DRs (n) | 38 | 37.3% | 764 | 17.0% |
| Age (median, IQR) | 48 | 13.75 | 50 | 18 |
| ½ AJ Ancestry (n) | 11 | 10.8% | 597 | 13.3% |
| ¾ AJ Ancestry (n) | 15 | 14.7% | 432 | 9.6% |
| # of Cancer-Free Female Relatives (mean, s.d.) | 3.5 | 1.5 | 3.7 | 1.4 |
| Sex (n female) | 74 | 72.5% | 3176 | 70.8% |
| BRCA1: 185delAG | 32 | 0.70% | - | |
| BRCA2: 5382insC | 18 | 0.39% | - | |
| BRCA2: 6174delT | 52 | 1.13% | - | |
| Women <40 (n) | 17 | 16.7% | 589 | 13.1% |
| Personal History of Cancer (n) | 2 | 11.8% | 3 | 0.5% |
| No Cancer in Reported Family (n) | 4 | 23.5% | 332 | 56.4% |
| No Cancer in 1DRs, Cancer in 2DRs and/or Aunts (n) | 5 | 29.4% | 154 | 26.1% |
| Cancer in 1DRs (n) | 8 | 47.1% | 103 | 17.5% |
| Age (median, IQR) | 36 | 5 | 33 | 8 |
| ½ AJ Ancestry (n) | 3 | 17.6% | 66 | 11.2% |
| ¾ AJ Ancestry (n) | 3 | 17.6% | 47 | 8.0% |
| # of Cancer-Free Female Relatives (mean, s.d.) | 3.2 | 1.7 | 3.6 | 1.3 |
| Women >40 (n) | 57 | 55.9% | 2587 | 57.7% |
| Personal History of Cancer (n) | 21 | 36.8% | 215 | 8.3% |
| No Cancer in Reported Family (n) | 13 | 22.8% | 1345 | 52.0% |
| No Cancer in 1DRs, Cancer in 2DRs and/or Aunts (n) | 24 | 42.1% | 754 | 29.1% |
| Cancer in 1DRs (n) | 20 | 35.1% | 488 | 18.9% |
| Age (median, IQR) | 52 | 12 | 52 | 16 |
| ½ AJ Ancestry (n) | 3 | 5.3% | 351 | 13.6% |
| ¾ AJ Ancestry (n) | 4 | 7.0% | 242 | 9.4% |
| # of Cancer-Free Female Relatives (mean, s.d.) | 3.6 | 1.3 | 3.8 | 1.4 |