Fig. 2.

High-resolution structure of M. tuberculosis heptameric form of EspB. A) Side and top views of the final cryoEM map using C7 symmetry at 3.37 Å resolution colored by monomer. B) Representations of side and top views of the final atomic model of EspB built into the cryoEM map colored by domain (PE in blue, linker in dark green, PPE in green, C-terminal domain in red). The secretion motifs YxxxD and WxG are colored in yellow. Limits of domains are indicated, and regions not reconstructed in the final model are represented by cross-hatching. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)