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. 2020 Aug 26;5(4):e000842. doi: 10.1136/esmoopen-2020-000842

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© Author (s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ on behalf of the European Society for Medical Oncology.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, any changes made are indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Network plots. (A) Progression-free survival (PFS) in endocrine-sensitive (ES) patients. (B) PFS in endocrine-resistant (ER) patients. (C) Overall survival (OS) in ES patients. (D) OS in ER patients. The width of the connecting lines is proportional to the number of trials comparing each pair of treatments, with bolder lines indicating comparisons with a higher number of trials. *±goserelin. AI, aromatase inhibitor; anti-andro, anti-androgen agent; CDK, cyclin-dependent kinases; CDK4/6i, CDK4/6 inhibitor; cont, continuous; F250, fulvestrant 250 mg; F500, fulvestrant 500 mg; int, intermittent; multiTKI, multi-tyrosine kinase inhibitor; pan-PI3Ki, pan-PI3K inhibitor; sapat, sapatinib; vistus., vistusertib.