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. Author manuscript; available in PMC: 2020 Aug 27.
Published in final edited form as: Ann Surg. 2020 Mar;271(3):509–518. doi: 10.1097/SLA.0000000000003093

FIGURE 2.

FIGURE 2.

Ablation of PPARα and GPR119 receptors did not impact body weight loss after VSG. A, Body mass, expressed as percent of baseline, after VSG decreased throughout the 11 postoperative weeks in WT and to a greater extent in PPARαKO mice compared with respective sham controls (aP < 0.05, main effect of surgery; bP < 0.05, main effect of genotype). B, The change in fat mass from presurgical to 11 weeks after surgery was reduced in VSG groups of both WT and PPARαKO mice compared with respective sham controls (aP < 0.001, main effect of surgery). C, VSG led to decreased body mass, expressed as percent of baseline, in GPR119KO and WT mice compared with respective sham controls throughout 10 weeks postoperatively (aP < 0.0001, time × surgery interaction). D, A similar decrease in fat mass after VSG was seen in GPR119KO and WT mice compared with respective sham controls from presurgical to 9 weeks after surgery (aP < 0.001, main effect of surgery).