FIGURE 7.

Lipid responses and macronutrient preference after VSG in CD36KO mice. A, Circulating plasma triglyceride levels were unchanged between genotype or surgery in both the fed and fasted state. B, Plasma cholesterol levels in both WTand CD36KO were improved with VSG after feeding (fed: ^aP < 0.001, main effect of surgery), and fasting (fasted: ^aP < 0.0001, main effect of surgery), without differences between genotypes. C, Hepatic triglycerides were elevated in CD36KO mice compared with WT mice but were reduced after VSG in both genotypes (^aP < 0.01, main effect of surgery; ^bP < 0.01, main effect of genotype). D, Hepatic cholesterol levels were unchanged between genotype or surgical groups. E, During a macronutrient preference test, WT mice increased carbohydrate intake after VSG, while CD36KO mice show no effect of surgery on carbohydrate intake (*P < 0.05). F, Both WT and CD36KO mice decrease preference for fat intake after VSG (^aP < 0.05, main effect of surgery). G, No change in average daily caloric intake was noted between either genotype or surgical intervention.