Table 2.
Top 10 differentially expressed genes identified via RNA sequencinga
| All | ||||||
|---|---|---|---|---|---|---|
| Rank | Gene symbol | Log FC | Log CPM | P | q | Complete gene name |
| 1 | IFI6 | 2.72 | 4.44 | 3.56e-08 | 4.30e-04 | Interferon alpha inducible protein 6 |
| 2 | IFI44 | 2.12 | 3.71 | 4.71e-08 | 4.30e-04 | Interferon-induced protein 44 |
| 3 | IFIT1 | 2.13 | 3.88 | 1.83e-06 | 3.82e-03 | Interferon-induced protein with tetratricopeptide repeats 1 |
| 4 | IFIT3 | 1.48 | 4.81 | 3.53e-06 | 6.34e-03 | Interferon-induced protein with tetratricopeptide repeats 3 |
| 5 | CMPK2 | 1.70 | 1.52 | 3.74e-06 | 7.62e-03 | Cytidine/uridine monophosphate kinase 2 |
| 6 | TFEC | 2.52 | 0.08 | 9.16e-06 | 1.13e-02 | Transcription factor EC |
| 7 | IFI44L | 2.44 | 4.06 | 1.23e-05 | 1.41e-02 | Interferon-induced protein 44 like |
| 8 | OAS1 | 2.45 | 2.92 | 1.47e-05 | 1.54e-02 | 2’-5’-Oligoadenylate synthetase 1 |
| 9 | IFI27 | 2.23 | 0.78 | 2.37e-05 | 2.30e-02 | Interferon alpha inducible protein 27 |
| 10 | SERPINA9 | 6.43 | 0.44 | 3.12e-05 | 2.82e-02 | Serpin family A member 9 |
| Male | ||||||
| Rank | Gene name | Log FC | Log CPM | P | q | Complete gene name |
| 1 | IFI44 | 2.52 | 3.71 | 6.44e-06 | 1.75e-02 | Interferon-induced protein 44 |
| 2 | SAMD9L | 2.74 | 3.73 | 1.19e-05 | 2.95e-02 | Sterile alpha motif domain containing 9 like |
| 3 | MGP | –4.59 | 0.81 | 3.14e-05 | 6.85e-02 | Matrix Gla protein |
| 4 | IFIT1 | 2.62 | 3.88 | 5.37e-05 | 8.09e-02 | Interferon-induced protein with tetratricopeptide repeats 1 |
| 5 | PDGFRA | 5.01 | 2.01 | 7.59e-05 | 1.07e-01 | Platelet-derived growth factor receptor alpha |
| 6 | IFI6 | 2.83 | 4.44 | 1.03e-04 | 1.21e-01 | Interferon alpha inducible protein 6 |
| 7 | CMPK2 | 2.00 | 1.52 | 1.48e-04 | 1.54e-01 | Cytidine/uridine monophosphate kinase 2 |
| 8 | C3AR1 | 2.32 | 1.28 | 2.42e-04 | 1.88e-01 | Complement C3a receptor 1 |
| 9 | OAS1 | 2.96 | 2.68 | 3.02e-04 | 2.02e-01 | 2’-5’-oligoadenylate synthetase 1 |
| 10 | IFI44L | 2.68 | 4.06 | 4.09e-04 | 2.23e-01 | Interferon-induced protein 44 like |
| Female | ||||||
| Rank | Gene name | Log FC | Log CPM | P | q | Complete gene name |
| 1 | ULBP1 | 2.72 | 2.45 | 2.16e-05 | 8.38e-02 | UL16 binding protein 1 |
| 2 | TFEC | 3.31 | 0.09 | 2.61e-05 | 8.84e-02 | Transcription factor EC |
| 3 | EPGN | 2.86 | 2.76 | 3.54e-05 | 1.07e-01 | Epithelial mitogen |
| 4 | TMEM47 | 2.34 | 3.98 | 7.62e-05 | 1.38e-01 | Transmembrane protein 47 |
| 5 | ZNF257 | 3.21 | 1.45 | 2.01e-04 | 2.10e-01 | Zinc finger protein 257 |
| 6 | MX1 | 3.31 | 5.31 | 2.10e-04 | 2.10e-01 | MX dynamin like GTPas2 1 |
| 7 | IFI6 | 2.63 | 4.44 | 2.81e-04 | 2.26e-01 | Interferon alpha inducible protein 6 |
| 8 | ZNF208 | 4.13 | 1.21 | 3.91e-04 | 2.26e-01 | Zinc finger protein 208 |
| 9 | BCAM | –2.06 | 1.69 | 4.72e-04 | 2.62e-01 | Basal cell adhesion molecule (Lutheran blood group) |
| 10 | PARM1 | 2.59 | 1.95 | 4.94e-04 | 2.62e-01 | Prostate androgen- regulated mucin-like protein 1 |
Abbreviations: CPM, counts per million; FC, fold change; RNA-Seq, RNA sequencing.
a RNA-Seq criteria used for ranking: P less than .01, absolute value log FC greater than 1.