Table 3.
Top 15 canonical pathways identified by RNA-sequencing
| All n = 1575 genes | Male n = 1279 genes | Female n = 1459 genes | |||
|---|---|---|---|---|---|
| Pathway | log, P | Pathway | log, P | Pathway | log, P |
| Role of cytokines and chemokines in inflammation | 9.97 | Role of cytokines in mediating communication between immune cells | 5.53 | Pathogenesis of multiple sclerosis | 6.41 |
| Role of cytokines in mediating communication between immune cells | 6.56 | Interferon signaling | 5.40 | Role of hypercytokinemia/ hyperchemokinemia in inflammation | 5.08 |
| Role of pattern recognition receptors in recognition of bacteria and viruses | 6.13 | Role of pattern recognition receptors in recognition of bacteria and viruses | 4.91 | Agranulocyte adhesion and diapedesis | 4.75 |
| Granulocyte adhesion and diapedesis | 5.16 | Role of hypercytokinemia/ hyperchemokinemia in inflammation | 4.72 | Granulocyte adhesion and diapedesis | 4.72 |
| Neuroinflammation signaling pathway | 4.99 | MODY signaling | 4.13 | Role of pattern recognition receptors in recognition of bacteria and viruses | 4.07 |
| Interferon signaling | 4.86 | Cellular effects of nitrous oxide signaling | 3.55 | Neuroinflammation signaling pathway | 3.88 |
| FXR/RXR activation | 4.65 | Altered T-cell and B-cell signaling in rheumatoid arthritis | 3.4 | Glucocorticoid receptor signaling | 3.79 |
| Atherosclerosis signaling | 4.56 | Neuroinflammation signaling pathway | 3.33 | Axonal guidance signaling | 3.23 |
| IL-10 signaling | 4.55 | Retinol biosynthesis | 3.15 | Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis | 3.21 |
| Hepatic cholestasis | 4.46 | Th2 pathway | 2.9 | Interferon signaling | 3.21 |
| LXR/RXR activation | 4.30 | Complement system | 2.71 | FXR/RXR activation | 3.11 |
| Superpathway of melatonin degradation | 3.8 | FXR/RXR activation | 2.68 | MSP-RON signaling pathway | 3.02 |
| Agranulocyte adhesion and diapedesis | 3.73 | Granulocyte adhesion and diapedesis | 2.65 | TREM1 signaling | 2.97 |
| Pathogenesis of multiple sclerosis | 3.48 | Communication between innate and adaptive immune cells | 2.61 | Cardiomyocyte differentiation via BMP receptors | 2.94 |
| LPS/IL-1 mediated inhibition of RXR function | 3.26 | Inhibition of matrix metalloproteases | 2.59 | Glutamate-dependent acid resistance | 2.76 |
Abbreviations: CPM, counts per million; FC, fold change; FXR, farnesoid X receptor; IL-1, interleukin 1; IL-10, interleukin 10; LPS, lipopolysaccharide; LXR, liver X receptor; MODY, maturity onset diabetes of young; RXR, retinoid X receptor.