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. 2020 Jul 10;27(9):2251–2260. doi: 10.1016/j.sjbs.2020.07.011

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Histopathological effect of Doxorubicin and protective effect of AHE in rat kidney (H&E staining, magnification 40X). Group 1: Renal section from control rats showing normal morphology. Group 2: renal sections from DOX-treated rats show degenerative changes, atrophy, capsule distortion, and cellular infiltrations. Group 3: Represents renal section from AHE alone treated rats. Group 4: AHE Low dose treatment showed mild tubular dilations. Group 5: AHE high dose treatment results in significant protection against DOX-induced renal injury. Group 6: Showed a protective effect of Silymarin treatment. AHE-A. hydaspica ethyl acetate fraction, DOX- Doxorubicin, GC-Glomerular capsule, BS-Bowman’s space, T- Tubules, CI- Cellular infiltrations, ABS-alteration in Bowman’s space, TD-Tubule dilation, CD- Capsule distortion, VC-vascular congestions, A- Atrophy.