Table 1.
Demographic and baseline clinical characteristics in the study's intention to treat (ITT) population.
| Variable | Rosuvastatin + Ezetimibe (n = 66) | Simvastatin + Ezetimibe (n = 63) | Total (n = 129) |
||
|---|---|---|---|---|---|
| Demographic | |||||
| Gender | Female | 55 (83.3%) | 53 (84.1%) | 108 (83.7%) | |
| Male | 11 (16.7%) | 10 (15.9%) | 21 (16.3%) | ||
| Age, mean (SD), y | Mean (SD) | 59.39 (8.7%) | 59.16 (9.6%) | 59.28 (9.1%) | |
| Race | White | 51 (77.3%) | 45 (71.4%) | 96 (74.4%) | |
| Non-white | 15 (22.7%) | 18 (28.5%) | 33 (25.6%) | ||
| BMI, mean (SD), kg/m2 | Overweight (25-30) | 25 (37.9%) | 25 (39.7%) | 50 (38.8%) | |
| Obesity (>30) | 29 (43.9%) | 25 (39.7%) | 54 (41.9%) | ||
| Normal (<25) | 12 (18.2%) | 13 (20.6%) | 25 (19.4%) | ||
| Medical history | |||||
| Diagnosis | Mixed dyslipidemia | 26 (39.4%) | 21 (33.3%) | 47 (36.4%) | |
| Primary hypercholesterolemia | 40 (60.6%) | 42 (66.7%) | 82 (63.6%) | ||
| Tobacco use | Never smoked/ex-smoker | 55 (83.3%) | 59 (93.7%) | 114 (88.4%) | |
| Smoker | 11 (16.7%) | 4 (6.3%) | 15 (11.6%) | ||
| Comorbidities | Controlled hypertension | 37 (56.1%) | 31 (49.2%) | 68 (52.7%) | |
| Uncontrolled hypertension | 13 (19.7%) | 11 (17.5%) | 26 (20.2%) | ||
| Diabetes | 23 (34.8%) | 21 (33.3%) | 44 (34.1%) | ||
| Ischemic heart disease | 2 (3.0%) | 2 (3.2%) | 4 (3.1%) | ||
| Chronic kidney disease | 0 (0.0%) | 1 (1.6%) | 1 (0.8%) | ||
| Metabolic syndrome | 48 (72.7%) | 38 (60.3%) | 86 (66.7%) | ||
| Blood Pressure, mean (SD) | |||||
| SBP (mmHg) | 129,14 (15,64) | 128,06 (15,82) | 128,61 (15,68) | ||
| DBP (mmHg) | 78,02 (10,13) | 78,86 (9,02) | 78,43 (9,58) | ||
| Lipid profiles, mean (SD) | |||||
| HDL-C (mg/dL) | 54,50 (12,20) | 55,03 (10,29) | 54,76 (11,27) | ||
| Non-HDL-C (mg/dL) | 194,58 (33,32) | 191,57 (27,16) | 193,11 (30,39) | ||
| TC (mg/dL) | 249,08 (34,72) | 246,62 (29,00) | 247,88 (31,95) | ||
| LDL-C (mg/dL) | 163,62 (29,56) | 160,89 (24,48) | 162,29 (27,12) | ||
| TG (mg/dL) | 154,71 (61,89) | 148,49 (51,75) | 151,67 (57,02) |
SD = Standard Deviation; BMI = Body Mass Index; SBP = Systolic Blood Pressure; DBP = Diastolic Blood Pressure; HDL-C = high density lipoprotein cholesterol; LDL-C = low density lipoprotein cholesterol; TC = Total Cholesterol; TG = Triglycerides