Table 5.

Relative risks for short-term morbidities affected by NAC and NNTs for benefit.

Outcome	Relative risk [95% CI]	P value	NNT [95% CI]
Composite morbidity scorea ≥2	0.451 [0.213–0.952]	0.037	3.869 [2.095–25.227]
IVH	0.396 [0.159–0.978]	0.047	4.332 [2.295–38.675]
IVH and/or death	0.364 [0.164–0.808]	0.013	3.143 [1.878–9.623]
BPD	0.100 [0.014–0.735]	0.024	3.444 [2.145–8.741]
BPD and/or death	0.238 [0.075–0.759]	0.015	3.431 [2.069–10.047]

NAC N-acetylcysteine, IVH intraventricular hemorrhage, BPD bronchopulmonary dysplasia, CI confidence interval, NNT number needed to treat.

^aComposite of culture-proven sepsis (any type), IVH grades 3 and 4, ROP grades 2–4, NEC grades 2–4, PVL, BPD, and/or death.