Fig. 4.
Trabecular bone was decreased after PR. (A, C) Representative reconstructed micro-CT images of the proximal tibial revealed that metaphyseal bone mineral density was decreased after PR in wild-type (A) and in Fgfr3ach mice (C). Upper panels show 2D images of the proximal tibia and lower panels show 3D images of the trabecular bone architecture. Scale bares indicate 300 μm. (B, D) Mean and SD of each relative parameter of bone morphometry are indicated. The bone volume/total volume (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N) of wild-type mice were significantly decreased after PR compared with those in Sham. Similarly in Fgfr3ach mice, these parameters were decreased after PR. The statistical differences shown on each graph are analyzed by paired t-test.