Fig. 6.

Hypertrophic zone was increased by PR. (A, C) The represented histological sections show the growth plate in the proximal tibia stained with Col X antibody of wild-type (A) and Fgfr3^ach mice (C). Squared parts are magnified in each lower image. Scale bares indicate 100 μm. (B, D) Mean and SD of each relative parameters of hypertrophic zone width and area of wild-type (A) and Fgfr3^ach mice (B) are indicated. Hypertrophic zone width and area were increased in PR of wild-type and Fgfr3^ach mice, but there was no statistical difference of these chondrocyte parameters in Fgfr3^ach mice. The statistical differences shown on each graph are analyzed by paired t-test.