Supplementary Fig. S1.

The effect of PR on endochondral ossification in Fgfr3^ach mice was not found in the fluorochrome labeling sections. (A) The represented sections show the metaphysis labelled with alizarin and calcein of Fgfr3^ach mice. Green and red areas were stained with calcein and alizarin, respectively. The unstained area and green area represent the area grown by 72 and 48 h, respectively. Squared parts are magnified in each lower image. Double arrows indicate the unstained area in the metaphyseal trabecular. Scale bares indicate 300 μm in upper images and 100 μm in lower images. (B) Mean and SD of relative longitudinal length of the unstained area and green area in Fgfr3^ach mice. The longitudinal length of both areas was not increased after PR. The statistical differences shown on each graph are analyzed by paired t-test.