Table 1.

Author and trial characteristics before and after the SPIRIT statement

	Before the SPIRIT statement	After the SPIRIT statement
Author characteristics
Authors per protocol (median, range)	8, 1 to 90	8, 2 to 80
One or more authors with expertise or experience in epidemiology or statistics (n, %)	50, 33.3%	48, 32%
Trial characteristics
Total planned sample size (median)	214.5	200
Multicentre status (n, %)	70, 46.7%	64, 42.7%
Protocol word length >3500 (n, %)	105, 70%	106, 70.7%
Industry funding (n, %)	8, 6%	10, 7%

SPIRIT, Standard Protocol Items: Recommendations for Interventional Trials.