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(A & B) Haematoxylin & Eosin. Brain parenchyma with infiltration by medium to large atypical lymphoid cells arranged in a diffuse pattern. The neoplastic cells are round to ovoid, having vesicular nuclei with some exhibiting prominent nucleoli. (C–E) Immunohistochemistry study with strong intense positivity for CD79a, diffuse positivity for BCL-2 and C-MYC. (F) Ki 67 (proliferation index) is 90%.
