Table 2.

Features supportive of necrotizing neutrophilic dermatoses [6,10,15].

Clinical features
Presence of erythematous or ulcerative plaques with violaceous borders  Multisystem involvement resembling shock with fevers and lack of an identifiable infectious source  Lack of crepitus
Histopathologic features
Neutrophil infiltrations and necrosis involving the fascia and/or muscle
Treatment course
A lack of clinical improvement or worsening in clinical picture seen with antibiotics or surgical intervention  Rapid response to systemic steroids
Presence of other known comorbidities or associations
Malignancies  Hematologic disorders  Pregnancy  Inflammatory diseases (Inflammatory bowel disease)  Medications (Granulocyte-colony stimulating factor, Radiation therapy)  History of pathergy, or development of or worsening of skin disease in areas of minor trauma (eg. sites of debridement or injections)