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Hematoxylin and Eosin staining of initial intraorbital optic nerve biopsy specimen (A) showing lymphocytes consistent with chronic inflammation. Hematoxylin and Eosin staining of the intracranial optic nerve from subsequent craniotomy (B) demonstrates tumor consistent with anaplastic astrocytoma (WHO grade III) and Ki67 staining (C) showed an index of 4–5% at the chiasmal margin.
