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. 2020 Jan 14;10(7):1253–1278. doi: 10.1016/j.apsb.2020.01.003

Figure 1.

Figure 1

The P53–MDM2/MDMX interactions. (A) MDM2 (surface)–P53 peptide (residues 15–29, colored in green) complex (PDB code: 1YCR). (B) The N-terminal domain of P53 showing π–π interaction between Phe19 and Trp23 (PDB code: 1YCR). (C) The superimposition of the structures of P53–MDM2 (PDB code: 1YCR, shown in cartoon) and P53–MDMX (PDB code: 3DAB, shown in cartoon) complex. The P53 transcriptional activation domain (TAD) fragment (residues 17–29) bound to MDM2 and MDMX is shown in yellow and orange, respectively. Phe19, Trp23 and Leu26 are shown in stick. Leu54, His96, Ile99 and Tyr100 in MDM2 are shown in green and stick, while Met53, Pro95, Leu98 and Tyr99 in MDMX are shown in light magenta.