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Identification of MDM2 inhibitor AV-15a based on the central valine concept. The crystal structure (PDB code: 6GGN) of MDM2 in complex with AV-15a (colored in yellow). The dashed line represents the H-bond. The MDM2 sub-pockets accommodating Leu26, Trp23 and Phe19 residues of P53 are labeled LEU, TRP and PHE, respectively. Adapted with permission from Ref. 64. Copyright © 2018 Elsevier Ltd.
