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Identification of MDM2 inhibitor RG7112 from Nutlin-3. (A) Crystal structure of MDM2 (shown in green surface) in complex with RG7112 (colored in yellow, PDB code: 4IPF). (B) Superposition of the crystal structures of MDM2 in complex with RG7112 (green) and Nutlin-3a (gold, PDB code: 4J3E).
