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Structure-based design of Nutlin-based MDM2/HDAC dual inhibitors. (A) Binding model of SCQ-14d-2 (red) in the MDM2 binding site (PDB code: 4IPF). (B) Binding mode of SCQ-14d-2 (red) in the active site of HDAC1 (PDB code: 4BKX). Adapted with permission from Ref. 45. Copyright © 2018 American Chemical Society.
