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Preliminary in vivo anticancer activity of compounds 25a and 30a. (A) Antitumor potency of compounds 25a and 30a in the HCT116 xenograft models implanted in BALB/c nude mice. Data were expressed as means ± SEM (n = 5 per group). **P < 0.01, ***P < 0.001, determined with Student's t test. (B) The change of body weight during the test.
