Table 1.
Correlation between the OPNI status and clinicopathological factors in 47 patients with OSCC.
| Characteristics | Total | OPNI status |
p-Value | |
|---|---|---|---|---|
| Low |
High |
|||
| n (%) | n (%) | |||
| Age(years) | ||||
| Median | 79 | 72.8 | 76.9 | |
| Range | 45–90 | 45–86 | 53–90 | |
| ≤65 | 10 | 5 (50.0) | 5 (50.0) | 0.391 |
| >65 | 37 | 13 (35.1) | 24 (64.9) | |
| Gender | ||||
| Male | 23 | 9 (39.1) | 14 (60.9) | 0.908 |
| Female | 24 | 9 (37.5) | 15 (62.5) | |
| Primary site | ||||
| Tongue | 16 | 8 (50.0) | 8 (50.0) | 0.743 |
| Mandible | 12 | 3 (25.0) | 9 (75.0) | |
| Maxilla | 7 | 3 (42.9) | 4 (57.1) | |
| Oral floor | 4 | 2 (50.0) | 2 (50.0) | |
| Buccal mucosa | 4 | 1 (25.0) | 3 (75.0) | |
| Palate | 4 | 1 (25.0) | 3 (75.0) | |
| cT-stage | ||||
| T1, T2 | 6 | 3 (50.0) | 3 (50.0) | 0.808 |
| T3 | 13 | 5 (38.5) | 8 (61.5) | |
| T4 | 28 | 10 (35.7) | 18 (64.3) | |
| cN-stage | ||||
| N0 | 13 | 7 (53.8) | 6 (46.2) | 0.377 |
| N1, 2b | 20 | 6 (30.0) | 14 (70.0) | |
| N2c | 14 | 5 (35.7) | 9 (64.3) | |
| cStage | ||||
| III | 8 | 4 (50.0) | 4 (50.0) | 0.358 |
| IV | 39 | 14 (35.9) | 25 (64.1) | |
| Differentiation | ||||
| Poor, Moderate | 33 | 10 (30.3) | 23 (69.7) | 0.083 |
| Well | 14 | 8 (57.1) | 6 (42.9) | |
| WPOI | ||||
| 1, 2 | 7 | 2 (28.6) | 5 (71.4) | 0.757 |
| 3 | 36 | 12 (33.3) | 24 (66.7) | |
| 4,5 | 4 | 2 (50.0) | 2 (50.0) | |
| RECISTa | ||||
| NC | 14 | 4 (28.6) | 10 (71.4) | 0.319 |
| PR | 18 | 8 (44.4) | 10 (55.6) | |
| CR | 8 | 3 (37.5) | 5 (62.5) | |
Abbreviation: OSCC: Oral squamous cell carcinoma. OPNI: Onodera's prognostic nutritional index. WPOI: Worst pattern of invasion. RECIST: Response Evaluation Criteria in Solid Tumors. CR: Complete response. PR: Partial response. NC: No change.
a
Seven patients could not evaluate the response to CRT. Chi-square test was used to examine the relationships between OPNI status and clinicopathologic factors.