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. 2020 Jun 4;7:100045. doi: 10.1016/j.toxcx.2020.100045

Fig. 6.

Fig. 6

Effect of cannabinoid and opioid antagonists on PnAn13 antinociception following prostaglandin E2-induced hyperalgesia. Rats received AM251 (a) or AM630 (b) intraplantarlly 2 h and 45 min after prostaglandin E2 (PGE2) injection (2 μg/paw). PnAn13 (10 μg/6 nmol) or saline (control) were intraplantar injected 10 min after the antagonists. Rats received Naloxone (c) intraplantarlly 2 h and 25 min after prostaglandin E2 (PGE2) injection (2 μg/paw). PnAn13 (10 μg/6 nmol) or saline (control) were intraplantar injected 30 min after the antagonist. The nociceptive threshold was measured 5 min after peptide or saline injection. Vertical bars represent MEAN ± SEM. n = 4 rats per group. Data were analyzed using ANOVA and Bonferroni post-test. p < 0.05 compared to PGE2 + Saline (*) or PGE2 + PnAn13 + Saline (#).