Figure 1.

CIC-Regulated Genes Are Not Increased by a Single i.c.v. ASO Injection into Atxn1^154Q/2Q Mice

(A and B) RNA-seq analysis of Atxn1 expression (black circle) and a set of CIC-regulated genes associated with increased risk of glioma (A) in the cerebellum at 18 weeks of age and (B) in the medulla at 28 weeks of age following a single i.c.v. injection of Atxn1-targeting ASO at 5 weeks of age. Horizontal dashed line indicates the position of p = 0.05. Atxn1^154Q/2Q uninjected n = 19, Atxn1^154Q/2Q vehicle n = 15, and Atxn1^154Q/2Q ASO353 n = 12.